Endocrine Abstracts

The incretin access is the descriptive term behind the observed phenomenon that one can elicit more insulin secretion from oral glucose than from an equivalent intravenous stimulus. The major causes of this are two gut hormones GIP and GLP-1.GLP-1 is secreted in the intestine by the L cells and has effects at the beta cell, in the brain, and on gastric motility. At the beta cell it binds onto G protein receptors which activate the metabolic pathways rela...